Efficacy of famotidine for the prevention of exercise-induced gastritis in racing Alaskan sled dogs     

Williamson KK  Willard MD  McKenzie EC  Royer CM  Payton ME  Davis MS 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2007,21(5):924-927

BACKGROUND: Omeprazole reduces the severity of exercise-induced gastritis but not the prevalence of gastric lesions in sled dogs. The frequent feeding of sled dogs during competition likely results in decreased absorption of omeprazole and, thereby, decreased efficacy. HYPOTHESIS: Famotidine, a histamine-2 blocker with good bioavailability in the presence of food, would reduce the incidence and severity of exercise-induced gastric disease in sled dogs. ANIMALS: Sixteen fit Alaskan sled dogs (4 female, 12 male, all intact, age 2-6 years). METHODS: Dogs were randomly assigned to treatment (22 mg famotidine PO q24h) or control groups (n = 8 per group). Famotidine was administered with a meal to the treatment group once daily for 7 days before a challenge and once during exercise. Control dogs were fed an identical diet as the principal group. The 16 dog team completed a 100-mile exercise challenge in 18 hours. A gastroscopy was performed 24 hours after the challenge. The appearance of the mucosa was scored by an individual by using a scoring system. RESULTS: Treatment with famotidine significantly reduced the severity score compared with control (P = .0004). No adverse effects of treatment were reported. CONCLUSIONS AND CLINICAL RELEVANCE: Famotidine is effective in reducing the severity of exercise-induced gastric disease in racing Alaskan sled dogs, with minimal to no adverse effects, and may be recommended for prophylactic use in short distance races.  相似文献   

Diagnosing appendicular osteosarcoma with ultrasound-guided fine-needle aspiration: 36 cases     

Britt T  Clifford C  Barger A  Moroff S  Drobatz K  Thacher C  Davis G 《The Journal of small animal practice》2007,48(3):145-150

OBJECTIVES: To determine the ability to obtain diagnostic cytology samples from appendicular bone lesions using ultrasound-guided needle aspirations. Secondary objectives were to compare cytological evaluations with histopathological results and to determine the utility of staining malignant mesenchymal cells for the presence of alkaline phosphatase. METHODS: Aspirations from 36 aggressive appendicular bone lesions with histological diagnoses were included in the study. Ultrasound was used to guide the needle to the medullary cavity or the adjacent soft tissue mass. The smears stained with Wright-Giemsa and nitroblue tetrazolium chloride/5-bromo-4-chloro-3-indoyl phosphate toluidine salt (NBT/BCIP) were examined. RESULTS: A diagnostic sample was obtained in 32 of the 36 cases. Of the 32 diagnostic samples, cytology indicated sarcoma, with a sensitivity of 97 per cent (confidence interval: 83 to 100 per cent) and a specificity of 100 per cent (confidence interval: 16 to 100 per cent). When a diagnosis of sarcoma was made on cytology, alkaline phosphatase staining indicated osteosarcoma, with a sensitivity of 100 per cent (confidence interval: 87 to 100 per cent). CLINICAL SIGNIFICANCE: The results of this study indicate that ultrasound-guided needle aspiration of aggressive bone lesions is a viable technique for identifying malignant mesenchymal cells and for diagnosing sarcomas. It is cost-effective and minimally invasive. Furthermore, identifying alkaline-phosphatase-negative malignant mesenchymal cells from a bone aspiration may rule out osteosarcoma, whereas alkaline-phosphatase-positive malignant mesenchymal cells are suggestive of osteosarcoma.  相似文献   

Catalyzing systemic movement of inward rectifier potassium channel inhibitors for antifeedant activity against the cotton aphid,Aphis gossypii (Glover)     

Flinn M O'Hara  Zhijun Liu  Jeffrey A Davis  Daniel R Swale 《Pest management science》2023,79(1):194-205

  相似文献   

Acute kidney injury from presumptive intramural ureteral hemorrhage secondary to diphacinone rodenticide exposure in a dog     

Nadene Oliver DVM  Kaila Rizzo DVM  DACVECC  Saya Press BVSc  MS  DACVECC  Stephanie Istvan VMD  DACVECC 《Journal of Veterinary Emergency and Critical Care》2023,33(1):112-117

  相似文献   

Prevalence of AO blood group and level of agreement for AO blood-typing methods in pet pigs from Louisiana     

Chiara Hampton DVM  MS  DACVAA  Shannon Dehghanpir DVM  MS  DACVP  Chance Armstrong DVM  MS  DACT  Clare Scully DVM  MS  DACT  Rose E. Baker BVMS  MS  DACVIM  Mark Mitchell DVM  MS  PhD  DEZM 《Journal of Veterinary Emergency and Critical Care》2023,33(5):549-558

  相似文献   

Comparison of 4 point-of-care techniques to detect correct positioning of nasogastric tubes in dogs (2020–2021)     

Meera Ramesh DVM  Aimee C Brooks DVM  MS  DACVECC  Elizabeth Thomovsky DVM  MS  DACVECC  Paula Johnson DVM  DACVECC  Carrie Fulkerson DVM  Nollie Parnell DACVIM  Hsin-Yi Weng BVM  MPH  PhD 《Journal of Veterinary Emergency and Critical Care》2023,33(5):501-508

  相似文献   

Successful management of minoxidil 5% toxicosis in 2 cats from the same household     

Tyler E. Johnson DVM  Meghan E. Fick DVM  MS  DACVECC  Jenica L. Haraschak MS  DVM  DACVECC  Mara E. Vernier DVM  Saki Kadotani DVM  MS  DACVIM 《Journal of Veterinary Emergency and Critical Care》2023,33(4):454-459

  相似文献   

Successful treatment of 5-fluorouracil toxicosis with hemodialysis     

Jessica S. Henry DVM  Simona Buoncompagni DVM  MS  DACVIM  Sheri Ross BSc  DVM  PhD  DACVIM  Stephanie A. Istvan VMD  DACVECC  Kaila Rizzo DVM  DACVECC  Larry D. Cowgill DVM  PhD  DACVIM  Saya A. Press BVSc  MS  DACVECC 《Journal of Veterinary Emergency and Critical Care》2023,33(3):388-392

  相似文献   

Evaluation of hemostatic derangements associated with canine anaphylaxis and the relationship to syndrome severity     

M. Ryan Smith DVM  DACVECC  Virginie A. Wurlod MS  Dr vet med  DACVECC  DECVECC  Chin-Chi Liu MS  MApStat  PhD 《Journal of Veterinary Emergency and Critical Care》2023,33(6):648-655

Objective

To describe hemostatic derangements associated with canine anaphylaxis and to assess for association with syndrome severity.

Design

Prospective observational study.

Setting

University teaching hospital.

Animals

Twenty-seven client-owned dogs, recruited from November 2018 to January 2022, diagnosed with anaphylaxis of varying severity were included. Study inclusion required presentation <6 hours after initiation of clinical signs, no medications or history of illness within the prior 2 weeks, lack of comorbidities expected to affect hemostasis, and lack of a disease state that could alternatively explain the clinical presentation.

Interventions

Blood samples were collected within the first hour of presentation for CBC, serum biochemistry, prothrombin time (PT), activated partial thromboplastin time (aPTT), and viscoelastic coagulation testing for use with a cartridge-based point-of-care device.

Measurements and main results

Clotting time and clot formation time were prolonged, alpha angle and maximum clot firmness were decreased, PT and aPTT were prolonged, and platelet counts were lower in severe cases compared to mild and moderate cases. There were no differences for any parameter between mild and moderate cases. The presence or absence of abdominal effusion was not associated with hemostatic status.

Conclusions

Global hemostatic derangements consistent with hypocoagulability are a prominent feature of severe anaphylaxis in dogs and should be considered for routine evaluation.  相似文献   

Retrospective evaluation of indications,transfusion protocols,and acute transfusion reactions associated with the administration of lyophilized canine albumin: 53 cases (2009–2020)     

Emilia Terradas Crespo LV  MS  DACVECC  Linda G. Martin DVM  MS  DACVECC  Elizabeth B. Davidow DVM  DACVECC 《Journal of Veterinary Emergency and Critical Care》2023,33(5):567-576

  相似文献